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After intragastric administration of 50 and 100 mg/kg L-carnitine for 30 days, axon area, myelin sheath area, axon diameter, myelin sheath diameter, and numerical density of the myelinated axons of injured sciatic nerve were similar to normal, and the function of injured sciatic nerve also improved significantly

298,311 Over-activation of glutamate-sensitive receptors in the brain can further degrade blood-brain barrier function and trigger excitotoxicity, neuroinflammation, increased oxidative stress, protein aggregation, mitochondrial dysfunction, and nerve cell death, and is considered a possible contributor to cognitive disorders, depression, reduced neuroplasticity, and neurodegenerative diseases like Alzheimer disease, Parkinson disease, multiple sclerosis, amyotrophic lateral sclerosis (ALS), and Huntington disease