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By the time the blood travels through your system, it becomes oxidized and turns into a thick, tarry substance called melena

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Across systems, common convergence nodes include endothelium, innate immune priming and extracellular matrix (ECM) remodelling, with disease-specific modifiers (lipid composition, iron handling, mitochondrial quality control) dictating phenotype (Schieber and Chandel 2014)