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Similarly, the FDA-approved drug Ponatinib is a potent small-molecule PD-L1 inhibitor that binds strongly to PD-L1 and, in vivo , delays tumor growth more effectively than an anti-PD-L1 antibody, while enhancing T-Cell activity, offering a promising alternative to antibody-based therapy (73)

TB-500 signals these cells to differentiate into myocytes (muscle cells), epithelial cells, or connective tissue cells depending on what the local environment needs

[DOI] [PMC free article] [PubMed] [Google Scholar] 22.Choueiri TK, Pal SK, McDermott DF, Morrissey S, Ferguson KC, Holland J, et al

Nat Commun 11 , 5430 (2020)