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Beyond cancer, PRODH dysfunction is also linked to neuropsychiatric and metabolic diseases, including schizophrenia 65,66 , and hyperprolinemia type I 67 , reflecting its broader role in regulating mitochondrial redox balance and prolineglutamate neurotransmitter metabolism

After digestion, the tissue was suspended in 20 mL RPMI 1640 (Gibco, C11875500) supplemented with 10% FBS and 1% Penicillin/Streptomycin

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Tu Y, Tan L, Tao H, Li Y, Liu H