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Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides

9.1 Integrated discussion on mechanistic evidence strength, gaps, and confounding factors (1) Strength ranking of core mechanistic evidence and prioritization for clinical translation Based on a systematic analysis of each nutrient's regulatory pathway, the mechanisms with the strongest evidence for clinical translation are prioritized as follows: Omega-3 polyunsaturated fatty acids (EPA/DHA) anti-inflammatory pathway: Supported by human RCTs (65, 69), which show that EPA/DHA supplementation reduces the levels of pro-inflammatory cytokines (IL-1, IL-6) and improves depressive symptoms

10.1124/jpet.119.258152 97 WangS.WangB.ShiY.MllerT.StegmeyerR

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