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showed that TMAO production was dependent on the gut microbiota and that mice treated with antibiotics failed to provide the required gut microbiota for TMAO production ( ApoE / mice without changing circulating cholesterol levels ( Ihubacter massiliensis and/or Emergencia timonensis in the human gut can synergistically contribute to diagnosing high-TMAO producers, with 43% sensitivity and 97% specificity ( Conclusion In recent years, there has been an increase in knowledge about the intestinal flora, which acts as a large endocrine organ

Under an imbalanced redox state, increased mtROS production can lead to alterations in the arterial wall [251]

L--L- -L-Acetyl-L-CarnitineL-L-CarnitineCH3CO- L-L- L--L--L-ACoA CoA -L- L--L-L--L--L- L--L-L--L- L- L- L-L- L-6 L- L- -L- -L- Metabolic approach to the enhancement of antitumor effect of chemotherapy: a key role of acetyl-L-carnitine.-L-Clin Cancer Res