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Furthermore, extended checkpoint activation may initiate the opposite of tolerance by exhausting Tregs or shifting antigen presentation dynamics, going against the original intent of therapy
Xu M, Wang X, Li Y, Geng X, Jia X, Zhang L, et al
E., Gissel-Nielsen, G
Corticosteroid medications, such as dexamethasone, also significantly decrease MAOA activity.[ref] A sudden suppression of MAO-A could increase dopamine and other neurotransmitter levels, sharpening awareness and quick decision-making, which makes sense in a situation that is suddenly stressful
