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The S1P-S1PR1 signaling pathway in astrocytes plays a role in BIPN, and the FDA-approved drug Fingolimod has demonstrated efficacy in both preventing and reversing BTZ-induced neuropathic pain (Stockstill et al., 2018)
In this scenario, physiological levels of testosterone can slightly increase oxidative stress and be neuroprotective against damage from subsequent exposures to oxidative stress (246)
doi: 10.1016/j.diabres.2021.109119 4 XuYWangLHeJBiYLiMWangTet al
Mitochondrial ROS have also been implicated in diabetic complications and progression of the underlying diabetic state
