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Similarly, increased risk of delayed development, intellectual disability and neurological as well as psychiatric problems associated with ASD, SCH, epilepsy and hypotonia was found to be the result of micro deletions in the long (q) arm of the chromosome in a region designated q21.1 (Knight et al., 1999

[DOI] [PubMed] [Google Scholar] 93.Seifman MA, Gomes K, Nguyen PN, Bailey M, Rosenfeld JV, Cooper DJ, et al

The dose-response curve between 8 and 12 mg shows diminishing returns, meaning 10 mg captures most of the benefit while potentially reducing some of the dose-related side effects seen at 12 mg