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Therefore, we recommend that when deciding on the use of high-dose antineoplastic combination therapy to prolong survival of patients having persistent and resistant GBM tumors, the long-term effects of this treatment on cross-resistance and MDR phenotype should be analyzed in primary cell cultures obtained from patients

After adding the solvent, gently swirl or roll the vial between your palms until the powder is fully dissolved

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In addition, CNS-associated macrophages are also located between astrocyte terminals and parenchymal vessels, where they extend into the perivascular space and participate in immune processes by phagocytosing debris (32)