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(2004) Cobalamin reduces homocysteine in older adults on folic acid-fortified diet: a pilot, double-blind, randomized, placebo-controlled trial
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These findings suggest that both NNMT and its product MNA increase Sirt1 protein expression, while Sirt1 is needed for the regulatory effects of NNMT and MNA on glucose metabolism [14]
This effect supports research exploring cellular energy dynamics, endurance enhancement, and overall mitochondrial efficiency within metabolic health models
