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One potential cause is when antibiotics or antimicrobials kill spirochetes, they break apart and release inflammatory substances such as cytokines into the bloodstream, triggering a strong immune response
Natural compounds like midazolam, vitamin B12, metformin, Cangrelor, and hesperidin have also shown anti-inflammatory effects in preclinical MIRI models, often by modulating macrophage polarization or inhibiting inflammatory pathways like NF-B (Xu et al., 2024)

[DOI] [PubMed] [Google Scholar] 21.Zhou Y, Yang M, Dong BR

140 (12), 2268S2285S
