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TH1579, MTH1 inhibitor, delays tumour growth and inhibits metastases development in osteosarcoma model

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Replenishes Glutathione, Your Master Antioxidant Glutathione is responsible for protecting your cells against oxidative stressthe kind of damage that accumulates over time and contributes to aging and chronic disease

Abbreviations ARE: Antioxidant response element CAT: Catalase Cys: Cysteine FFAR: Free fatty acid receptor GSH: Glutathione reduced GPR: G protein-coupled receptor GST: Glutathione-S-transferases Glu: Glutamate HO-1: Heme oxygenase-1 H 2 O 2 : Hydrogen peroxide Keap-1: Kelch-like ECH-associated protein 1 MAPK: Mitogen-activated protein kinase NF-B: Nuclear factor kappa beta Nrf2: Nuclear factor-erythroid 2 related factor 2 ROS: Reactive oxygen species SOD: Superoxide dismutase STAT3: Signal transducer and activator of transcription 3 References Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, Morelli L, Canani RB, Flint HJ, Salminen S, Calder PC, Sanders ME (2014) Expert consensus document