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NLR family pyrin domain-containing protein 1 (NLRP1) and caspase activation and recruitment domain 8 (CARD8) can detect certain infections because each harbors an inhibitory domain that can be modified by bacterial or viral enzymes and targeted for proteasomal degradation [307]

Impact of intermittent fasting on health and disease processes

But, if you're really missing that morning cup of joe, make sure to enjoy it at least 3 hours before lying down to give your body time to digest the caffeine and avoid any unwanted reflux symptoms

Lang R, Lang T, Bader M, et al
