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It is a well-tolerated compound with a clean safety profile and a genuinely interesting mechanism that, so far, has produced results in humans that fall short of what animal models predicted

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As the identified di-, hexa- and decadepsipeptides are not in line with the proposed biosynthetic assembly of three ready-made tetradepsipeptides 8,9 , these findings prompted us to ask whether the candidate depsipeptide esters are released from chemically unstable NRPS-bound PCP- S -ester or TE- O -ester intermediates of cereulide biosynthesis upon transesterification with ethanol, or are formed as artifacts by esterification of free depsipeptides or as cereulide degradation products released upon ethanolysis

Preclinical and clinical evidence of NAD+ precursors in health, disease, and ageing