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RNA interference targeting hepatic angiopoietin-like protein 3 results in prolonged reductions in plasma triglycerides and LDL-C in human subjects
(PubMed) Delaney CL, Spark JI, Thomas J, Wong YT, Chan LT, Miller MD
Creates opposing signals: MT2 suppresses appetite via MC4R while the GHRP compound increases it via ghrelin receptor activation

The tested compounds were added together with non-sterol-modified Sonic Hedgehog (Shh) or Smoothened agonist (SAG) to LIGHT2 cells
