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The epigenetic effects of alcohol on hepatic and neuronal tissue are well documented (Shukla et al., 2008)
GazullaJGarca-RubioSRuiz-GazullaCModregoP
If antioxidant defenses and Phase 2 conjugation pathways are insufficient, these intermediates may accumulate, increasing oxidative stress and cellular injury rather than promoting clearance (4)
DSIP for Neuroprotection and Withdrawal Management DSIP has also been suggested to potentially interact with the opioid receptors, which may not only mediate the peptides effects on sleep onset and architecture but also have potential benefits in subjects with addiction
