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Small size IONPs were sometimes used as therapeutic agents other than the carriers

This review briefly discusses the endogenous (mitochondria, NADPH, xanthine oxidase (XO), Fenton reaction) and exogenous (e.g., smoking, radiation, drugs, pollution) sources of ROS (superoxide radical, hydrogen peroxide, hydroxyl radical, peroxyl radical, hypochlorous acid, peroxynitrite)

For example, aging is associated with deficiency of the antioxidant glutathione (GSH) [9,10,11,12,13,14,15,16,17,18,19], elevated oxidative stress (OxS) [9,10,11,12,13,14], impaired mitochondrial function and inflammation [11,13,14,20,21,22,23,24], and these defects also occur in AD [25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41]

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