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Deficiency of glutathione in patients with untreated diabetes: a new hypothesis for the role of oxidative stress in the pathogenesis of diabetes and its complications

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Secondly, the redox status of the cell affects many of the enzymes in one-carbon metabolism including MATI, MATIII, MS, BHMT, as well as CBS and GCS in the transsulfuration pathway, and therefore one cannot evaluate GSH metabolism without including the methionine and folate cycles