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Description
L-carnitine reverses methotrexate-induced nephrotoxicity in experimental rat model: insight on SIRT1/PGC-1/Nrf2/HO-1 axis

Multiple transcription factors, including Hoxa1 and Bcl-2 (B-cell lymphoma protein 2), can affect the transcription of possibly hazardous genes in the open and uncondensed chromatin, which increase apoptosis regulation while decreasing morphogenesis (essential for differentiation of organ) and cellular proliferation, respectively (Ornoy, 2009)

H., Bamlet, W

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