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Using 18F-fluorodeoxyglucose positron emission tomography, researchers have detected significantly elevated glucose metabolism in human atherosclerotic plaques, particularly within lipid-rich necrotic cores and regions densely infiltrated by immune cell (106, 107), high-risk plaques, in particular, display increased glycolytic activity (108), and as a metabolic hallmark of trained immunity (109, 110)

Additionally, recent studies suggest that a high sugar diet can alter the gut microbiota leading to age-associated illness 6,7,8,9

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