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Overall, patients with HIV demonstrate a preferential loss of Th17 cells, leading to increased susceptibility to opportunistic co-infections and compromised gut mucosal defenses against bacterial and fungal infections

Skin Aging Of all the organs, the skin is the most conspicuous to display signs of aging or dermal changes, which are due to chronological (intrinsic) and photoaging (extrinsic) mechanisms [2, 10, 14]

We then summarise the disparate practice in B12 replacement internationally and highlight the more novel methods of B12 administration, including subcutaneous, intra-nasal and sublingual modes in comparison to intramuscular and oral routes

Mayo Clinic - Vitamin B12 deficiency anemia National Institutes of Health (NIH) - Vitamin B12 Fact Sheet for Health Professionals Harvard Health Publishing - Vitamin B12 deficiency: What to know NHS (National Health Service) - Vitamin B12 or folate deficiency anemia American Academy of Family Physicians - Diagnosis and Treatment of Vitamin B12 Deficiency