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The mechanism of action of FOXO4-DRI lies in its ability to competitively interfere with the binding of endogenous FOXO4 to the p53 proteina central regulator of the cell cycle and apoptosis

111,112 Taking a water-soluble CoQ10 (160 mg) plus other nutrients (B vitamins, vitamin E [36 mg], choline [100 mg], melatonin [1 mg], ginkgo phytosome [80 mg], and milk protein hydrolysate [150 mg]) appeared to protect against hearing damage and tinnitus in a pilot trial that included 26 cancer patients being treated with cisplatin (Platinol), a chemotherapy agent known to have ototoxicity

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