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The rescue effects of these agonists were specifically reversed by their corresponding inhibitors, SKF96365, HC067047, GsMTx-4 and Pyr3, further supporting the involvement of these channels in mediating the Ca 2+ signal downstream of XKR8 (Fig

The accumulation and magnification of these metals in living organisms can lead to poisoning, destabilization of water ecosystems, significant threats to public health, and long-term impacts on entire ecosystems 6,7,8

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Using EMD, Rasperini et al
