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Conclusions MSC-based regenerative treatment of the degenerated IVD seems promising

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Mitochondrial and lysosomal dysfunction, dysregulated iron metabolism, and accumulation of ROS are considered to be pivotal elements in the pathogenesis of PD, ultimately leading to neuronal degeneration and death (Matak et al., 2016

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CNs induce anxiety and depression, negatively impact careers and relationships, cause pain and pruritus, and present a constant visual reminder of a relentlessly progressive disease despite our best current treatments

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The most common types of these anemias are megaloblastic anemia or iron deficiency anemia caused by folate or B12 deficiency

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