glutathione glutamine synthetase Synthetase: Diverse Regulation and Functions of an Ancient Enzyme Glutamine Synthetase: Localization Dictates Outcome
Description
Given its essential role in the detoxification of lipid hydroperoxides, and its overexpression in most of myeloid malignancies, GPX4 inhibition has emerged as a promising therapeutic strategy to specifically trigger ferroptosis and eradicate myeloid leukemia cells
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PMID: 33 LuLCaiYLuoXWangZFungSHJiaHet al
[DOI] [PubMed] [Google Scholar] 36.Logan DT, Andersson J, Sjoberg BM, Nordlund P
