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It concentrates its effects near the administration site, promoting collagen synthesis, reducing local inflammation, and stimulating growth factors directly in damaged tissue

doi: 10.3389/fcell.2025.1719332 Received 06 October 2025 Revised 17 November 2025 Accepted 19 November 2025 Published 10 December 2025 Volume 13 - 2025 Edited by Liang Ma, Huazhong University of Science and Technology, China Reviewed by Yu Han, Shanghai Jiao Tong University, China Liang Kang, First Affiliated Hospital of Anhui Medical University, China Yongzhi Cui, Shanghai Jiao Tong University, China Updates Copyright 2025 Wang, Xu, Hua, Mao, Zhang, Ma and Lu

The surgerys complexity and location affect the risk of injury

Variability in study protocols, glutamine dosages, and patient cohorts may contribute to the divergent findings, emphasizing the need for standardized approaches, and larger, well-controlled trials to elucidate the true impact of glutamine supplementation on mucositis and other treatment-related toxicities