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These were cells of sod1 and sod2 strains without activity of superoxide dismutases enzymes which scavenge superoxide anion radical from the cytoplasm and mitochondrial matrix, respectively, as well as strains lacking activity of Msn2p and Msn4p, which activate the environmental stress response programme

The main differences across comparison categories are: Mechanism of Action: advantage goes to Dihexa

Patients who have a deteriorating response to L-dopa, experience fluctuations in response to L-dopa, or have a limited clinical response to L-dopa secondary to an inability to tolerate higher doses are appropriate candidates