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Dysregulated iron metabolism is characterized by increased expression of iron retention genes (e.g., hepcidin [HAMP], ferritin heavy and light chains [FTH1/FTL]) and reduced iron export via ferroportin (FPN), leading to intracellular iron accumulation (39)

The intracerebroventricular (ICV) injection of the DEETGE-Cal-Tat peptide showed an increased expression of Nrf2- regulated genes and marked neuroprotective and cognitive-preserving effects in mice subjected to brain injury [301]

Chng oxy ha mnh m: L-Glutathione l mt cht chng oxy ha t nhin, gip bo v c th khi cc gc t do, lm chm qu trnh lo ha v ngn nga cc du hiu nh np nhn, vt chn chim