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Subsequently, nucleus translocation of PARP1-dependent AIF interacts with macrophage migration inhibitory factor (MIF) to format the AIF-MIF complex, which further induces the DNA breakage and ultimately results in parthanatos [140]

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Anemia of inflammatory disease This produces a mild to moderate normocytic normochromic anemia (Chevier et al 2020) and is the most common cause of a non-regenerative, weakly regenerative or inadequately regenerative anemia of this type, particularly when cancer-associated anemias are included under this category