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While GSH has long been recognized as a key brain antioxidant, its role in neurodegenerative diseases is now being unraveled with mechanistic clarity: future research will likely focus on activating astrocytic Nrf2 signaling to enhance glutamate cysteine ligase (GCL)-mediated GSH synthesis, exploring the role of MCT1/2 transporters in neuronal GSH precursor supply, and dissecting how oxidative stress modulates microglial activation via pathways like NF-B-dependent proinflammatory cytokine secretion (Sun et al., 2022)

We speculate that the main reason for not showing a significant difference is that the MEXAMETER used to measure the melanin index in this study cannot distinguish between the two types of melanin, eumelanin and pheomelanin, resulting in greater individual differences and variability

This phenomenon was mitigated following the adding of APS (Fig

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