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Key features of rhinophyma Thickened, oily skin on the nose Enlarged pores and visible oil glands Bulbous, irregular shape to the nose More common in men Causes of rhinophyma Its linked to chronic inflammation and overgrowth of sebaceous (oil) glands Not caused by alcohol (a common myth), though alcohol may worsen rosacea symptoms Why may Accutane help with rhinophyma

Its primary mechanism involves upregulation of the hTERT gene, which encodes the catalytic subunit of telomerase -- the enzyme that adds TTAGGG repeats to chromosome ends

Studies carried out using epithelial cell lines and animal models showed that gliadin was able to induce apoptosis of intestinal epithelial cells through a direct toxic effect (251), including enterocyte atrophy, villi shortening, decreased epithelial disaccharidase activity, increased expression of HLA molecules, and intraepithelial inflammatory activation