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When a cell over-expresses NNMT, it does two costly things at once: it burns through methyl-donor capacity, and it diverts nicotinamide away from NAD+ regeneration into an inert metabolite (1-methylnicotinamide) that gets excreted

doi: 10.1371/journal.pone.0062934

When Titan obtains permission for the expanded labeling of their product from the regulatory agencies, clinical data could then be gathered from these additional cases and submitted as evidence of effectiveness to the insurance agencies

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