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The clinical picture of cats with LC varies widely and has significant overlap with other forms of hepatobiliary disease in cats, including NC.4, 9 Although some studies describe a predominance of older cats, 3 others describe more younger cats.22, 23 Nonspecific clinical signs, including anorexia, lethargy, vomiting, and weight loss, may be chronic and intermittent.3, 6, 22 Physical examination findings may include icterus, hepatomegaly, or ascites, but none are consistent findings

Although our previous in vitro studies demonstrated that conductive scaffolds can enhance Schwann cell proliferation and neural differentiation of ADSCs 24,25,60 , our in vivo findings indicate that providing a conductive substrate alone is insufficient in the dynamic and complex environment of injured nerve tissue

In addition to the GSH-dependent LDE detoxification pathway, the aldo-keto reductase (AKR) and aldehyde dehydrogenase (ALDH) enzyme classes metabolize and detoxify LDEs (6063)

doi: 10.1007/s00394-018-1790-2 37 ZhangCYLiuTHWangW