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Bellavance, M

In HCC driven by obesity and nonalcoholic steatohepatitis, the downregulation of CPT2 leads to the accumulation of acylcarnitines, among which C18:1-carnitine enhances spheroid formation by HCC cells through STAT3 activation, indicating that the accumulation of acylcarnitine can promote the development of liver cancer [212]

Inclusion criteria: clinical studies, case reports, and case series where PTX has been used to treat PD in humans, as well as systematic review articles in which the therapeutic use of PTX and the results were explicitly discussed

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