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Murakami et al

The results from this study may reveal an important basis underlying the gender-associated differences in the longevity and the susceptibility to certain age-related diseases, and also further suggest that the decreased synthesis, which is mainly due to the down regulation of GCL gene expression, may be responsible for the age-associated decline in GSH content

Understanding Beta-Glucuronidase: The Hidden Enzyme That Affects Hormones and Detoxification In the intricate world of human metabolism, some enzymes operate quietly in the background but exert massive influence on health and disease

Nevertheless, there are also studies showing that neither neomycin nor gentamicin exposure has an impact on the level of mitophagy, suggesting a mitophagy-independent pathway of aminoglycoside ototoxicity (Setz et al., 2018)