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We identify a compound that degrades MYC, A80.2HCl, which induces MYC degradation at nanomolar concentrations, restores pRB1 protein levels and re-establish sensitivity of MYC high-expressing cancer cells to CDK4/6i

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In trials assessing fat density, tesamorelin increased both VAT and subcutaneous adipose tissue density, suggesting an enhancement in fat quality independent of quantity changes 3

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Recently, mRNA gene editing systems have also been employed for inherited retinal diseases, with successful gene editing in retinal epithelium and Mller glia [285]

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p53 modifications: exquisite decorations of the powerful guardian

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