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2012;03(10) doi: 10.4172/2153-2435.1000e139

Protects Skin from Aging and UV Damage Ergothioneine builds up in skin cells through the OCTN-1 transporter and helps counter several key drivers of skin aging: Sun damage: Absorbs UV light and helps prevent UV-triggered DNA damage [14] Collagen loss: Inhibits MMP-1, the enzyme that breaks down collagen [15] Uneven tone: Clinical data show reduced wrinkles, age spots, and hyperpigmentation by suppressing excess melanin [15] Loss of firmness: Protects collagen and elastin and supports better hydration and elasticity [15] Inflammation: Its anti-inflammatory properties help calm acne, rosacea, psoriasis, and atopic dermatitis, and in some models it outperforms coenzyme Q10 and vitamin C against free radicals [15] These benefits have been observed with both topical ergothioneine and oral supplementation

In response to Mtb infection, macrophages strongly upregulate the expression of indoleamine 2,3-dioxygenase enzymes (IDO1, IDO2, and TDO), that convert L-tryptophan into L-kynurenine

Yepiskoposyan, J