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In the phase III trial, AVP-825 showed an earlier onset and consistent responses across multiple migraine attacks compared with 100 mg oral sumatriptan, supporting the clinical value of breath-driven delivery designed to improve deposition beyond the nasal valve (Lipton et al., 2017
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10.1038/mtm.2015.43 92 SongH.YangP.HuangP.ZhangC.KongD.WangW
R., Heintzelman, M
