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DOP has also been reported to be associated with ferroptosis, and iron overload can promote osteoclast differentiation and bone resorption through ROS production (113)

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Based on research that was done in 2019, where the cumulative prevalence of PLTDS in the United States is estimated to be high and continuing to increase, affecting close to two million individuals [4], it is essential to explore innovative solutions for this expanding public health crisis

Self-administration could lead to incorrect technique or adverse reactions