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LRRK2 and PINK1 form a functional protein kinase pair to modulate TH and DA levels in dopaminergic neurons, and this observation has been validated in multiple in vitro and in vivo PD models, including human dopaminergic neurons and midbrain organoid models derived from patient cell-induced iPSCs [44]
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[13] An example is plasma , the liquid component of blood, which, due to the presence of salts and proteins (primarily albumin in humans), has an osmolarity similar to that of the cytosol
