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Zhurnal Nevrologii i Psikhiatrii Imeni SS Korsakova, 108 (5), 71-75

Abbasi, G

Eight Hypotheses Why (also meaning we'll piss everybody off with this post, ha!) Removing barriers to drug treatment Increased distribution of naloxone Law enforcement operations at US-Mexico border Cartel arrests and fentanyl shipment restriction Depletion of susceptibles Marijuana legalization Xylazine reducing overdose severity Transition to smoking & price Let's put one hypothesis to rest: Reductions in opioid analgesic prescribing is not driving the changes in overdose rates

Only then can a regulatory submission be prepared followed by an independent review by agencies such as the EMA or FDA