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Description
Glutamic acid is the most abundant amino acid in the diet, and a high level of free glutamate in some foods results in an umami taste (e.g., tomatoes, mushrooms, cheeses) ( TDR4 -silenced and control tomato fruit, and four of these were upregulated, including glutamate dehydrogenase ( GDH1 ) (1.11-fold), glutamine synthetase ( GS ) (6.04-fold), glutamate decarboxylase 1 ( GAD3 ) (2.20-fold), and a gene encoding isocitrate dehydrogenase (1.99-fold) (Supplementary Table S2)

Intracellular methionine level of CD19 + B cells is largest increased after CpG/IFN-/BCR crosslinking simulation, and methionine commits the differentiation of CD19 + B cells through driving the histone modification H3K27me3 of BACH2 (a vital transcriptional factor for B-cell differentiation), and this process refers to activation of spleen tyrosine kinase (Syk) or mTORC1 signaling and up-regulation of expression of methyltransferase enhancer zeste homolog 2 (EZH2) (105)

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