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In addition, while all of the scales demonstrate good reliability, the validity of measurement of motor performance in children with different severities of SMA is in question and the relationship to pathophysiology unclear
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A subset of immune cells, including macrophages, neutrophils, T cells, and B cells, have been implicated in ferroptosis or are intrinsically sensitive to ferroptosis due to changes in gene expression during maturation, which can significantly affect both innate and adaptive immunity, as recently reviewed in detail by Chen et al
