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Martn-Estal I, de la Garza RG, de Cortzar IC (2015) Intrauterine growth retardation (IUGR) as a novel condition of insulin-like growth factor-1 (IGF-1) deficiency

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Shown to improve epithelial barrier integrity, reducing gut permeability and inflammatory cell infiltration

14 - 19 This however, directly holds that cytoprotective agent would be effective prophylactically (given before injury able to protect stomach mucosa) as well as therapeutically (given after injury, with the pre-existing lesion, able to rescue stomach mucosa)