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2009;297(3):E620E628

As 2 agonists lack the GABAergic activity to prevent and treat DT or seizures, they can only be used as adjunctive therapy to reduce autonomic hyperactivity that cannot be controlled by BZD alone.3, 80, 86 Several studies demonstrated a BZDsparing effect with significant reduction in BZD requirement.87, 88, 89 8.3.4

doi: 10.1016/j.kint.2020.03.038
