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Drugs that are completely retained within the vascular compartment, on the other hand, would have a minimum possible volume of distribution equal to the blood component in which they are distributed, eg, 0.04 L/kg body weight or 2.8 L/70 kg ( Table 32 ) for a drug that is restricted to the plasma compartment

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Nag SA, Qin JJ, Wang W, Wang MH, Wang H, Zhang R

First and foremost, to enable large-scale manufacture, low-toxicity carriers must be used for the synthesis of nanoparticles, and the production process must be made simpler