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The findings of the SURMOUNT OSA trial supported this hypothesis, showing a significant improvement in AHI, hypoxic burden and sleep quality with tirzepatide compared to placebo at 52 weeks 38

These changes are related to the sodium-retaining properties of GH and IGF-1 via ENaC in the renal distal tubules ( vide supra ) and can be reversed if patients undergo effective treatment of the GH-producing tumor [100]

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