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Description
Peripheral CD4+ T-cell tolerance is induced in vivo by rare antigen-bearing B cells in follicular, marginal zone, and B-1 subsets
This is because of the variations in a pigment called melanin
10.3390/cancers16132490 Cancers (Basel)
reported that the small ARF-like GTPase Arl8b regulates this mechanism and can be inhibited by the Rab7 GTPase competitive inhibitor CID1067700
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