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Toronto Classification of Distal Symmetric Diabetic Polyneuropathies 14 1) Possible DSPN : The presence of symptoms or signs of DSPN may include the following: symptomsdecreased sensation, positive neuropathic sensory symptoms (e.g., asleep numbness, prickling or stabbing, burning or aching pain) predominantly in the toes, feet, or legs

This phase lasts 30 to 90minutes and is an important window for the use of abortive medications.64,74,75 3 Emetic phase

pmid:9275188 45

Folate/folic acid is crucial during pregnancy in preventing neural tube defects (e.g., spina bifida and anencephaly), supporting DNA synthesis and cell growth, and forming red blood cells [56]